Assessment of structural diversity in combinatorial synthesis

被引：50

作者：

Fergus, S ^{[1
]}

Bender, A ^{[1
]}

Spring, DR ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.cbpa.2005.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This article covers the combinatorial synthesis of small molecules with maximal structural diversity to generate a collection of pure compounds that are attractive for lead generation in a phenotypic, high-throughput screening approach. Nature synthesises diverse small molecules, but there are disadvantages with using natural product sources. The efficient chemical synthesis of structural diversity (and complexity) is the aim of diversity-oriented synthesis, and recent progress is reviewed. Specific highlights include a discussion of strategies to obtain structural diversity and an analysis of molecular descriptors used to classify compounds. The assessment of how successful one synthesis is versus another is subjective, therefore we test-drive software to assess structural diversity in combinatorial synthesis, which is freely available via a web interface.

引用

页码：304 / 309

页数：6

共 35 条

[1] Chemical genetic approaches for the elucidation of signaling pathways [J].