The accelerated development of an optimized synthesis of 1,2,4-oxadiazoles: application of microwave irradiation and statistical design of experiments

被引：67

作者：

Evans, MD

Ring, J

Schoen, A

Bell, A

Edwards, P

Berthelot, D

Nicewonger, R

Baldino, CM

机构：

[1] ArQule Inc, Dept Chem, Woburn, MA 01801 USA

[2] Pfizer Ltd, Global Res & Dev, Lib Design & Prod Grp, Sandwich Labs, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 52期

关键词：

oxadiazole; microwave; design of experiments; amidoxime; optimization;

D O I：

10.1016/j.tetlet.2003.10.055

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report the development of an optimized microwave-assisted synthesis of 1,2,4-oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0(TM)) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1,2,4-oxadiazoles. (C) 2003 Published by Elsevier Ltd.

引用

页码：9337 / 9341

页数：5

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