Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies

被引：8

作者：

Hernandez-Rocamora, Victor M. ^{[2
]}

Reulen, Sanne W. A. ^{[1
]}

de Waal, Bas ^{[1
]}

Meijer, E. W. ^{[1
]}

Sanz, Jesus M. ^{[2
]}

Merkx, Maarten ^{[1
]}

机构：

[1] Eindhoven Univ Technol, Biol Chem Lab, Dept Biomed Engn, NL-5600 MB Eindhoven, Netherlands

[2] Univ Miguel Hernandez, Inst Biol Mol & Celular, Elche 03202, Spain

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 21期

关键词：

COLLAGEN; BINDING; ORGANIZATION; CNA;

D O I：

10.1039/c0cc05605g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A modular self-assembly strategy is presented that allows the non-covalent synthesis of multivalent protein dendrimers using the strong interaction between choline-functionalized dendrimers and the choline binding protein C-LytA. Choline dendrimers displaying fusion proteins of C-LytA and the collagen binding protein CNA35 represent attractive multivalent targeting ligands for collagen imaging.

引用

页码：5997 / 5999

页数：3

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