Paternal origin of trisomy 21 following intracytoplasmic sperm injection (ICSI)

被引：10

作者：

Bartels, I ^{[1
]}

Schlösser, M ^{[1
]}

Bartz, UG ^{[1
]}

Pauer, HU ^{[1
]}

机构：

[1] Univ Gottingen, Inst Human Genet, D-37073 Gottingen, Germany

来源：

HUMAN REPRODUCTION | 1998年 / 13卷 / 12期

关键词：

genetic risk; intracytoplasmic sperm injection; male infertility; pregnancy loss; trisomy;

D O I：

10.1093/humrep/13.12.3345

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

One important aspect in the debate on the genetic risks associated with intracytoplasmic sperm injection (ICSI) is the possible increased rate of chromosomal abnormalities in resulting pregnancies. ICSI was performed in a 27 year old man with asthenoteratozoospermia and his 25 year old wife. There was a spontaneous miscarriage at 9 weeks of gestation. Cytogenetic investigation revealed trisomy 21. Analysis of two polymorphic microsatellite markers showed that the additional chromosome was paternal. This is in contrast to the fact that the vast majority of trisomic concepti are maternal in origin. Identifying the parent of origin in trisomic conceptions achieved by ICSI may reveal whether ICSI is associated with an increased risk of paternally derived aneuploidy.

引用

页码：3345 / 3346

页数：2

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