New features of the blocks database servers

被引:73
作者
Henikoff, JG [1 ]
Henikoff, S [1 ]
Pietrokovski, S [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA
关键词
D O I
10.1093/nar/27.1.226
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Blocks are ungapped multiple sequence alignments representing conserved protein regions, and the Blocks Database consists of blocks from documented protein families. World Wide Web (http://www.blocks. fhcrc.org) and Email (blocks@blocks.fhcrc.org) servers provide tools for homology searching and for analyzing protein family relationships. New enhancements include a multiple alignment processor that extends the use of these tools to imported multiple alignments of families not present in the database and a PCR primer designer that implements a new strategy for gene isolation.
引用
收藏
页码:226 / 228
页数:3
相关论文
共 12 条
  • [1] Novel developments with the PRINTS protein fingerprint database
    Attwood, TK
    Beck, ME
    Bleasby, AJ
    Degtyarenko, K
    Michie, AD
    ParrySmith, DJ
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (01) : 212 - 216
  • [2] The PROSITE database, its status in 1997
    Bairoch, A
    Bucher, P
    Hofmann, K
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (01) : 217 - 221
  • [3] Automated protein sequence database classification. I. Integration of compositional similarity search, local similarity search, and multiple sequence alignment
    Gracy, J
    Argos, P
    [J]. BIOINFORMATICS, 1998, 14 (02) : 164 - 173
  • [4] Recent enhancements to the Blocks Database servers
    Henikoff, JG
    Pietrokovski, S
    Henikoff, S
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (01) : 222 - 225
  • [5] Henikoff S, 1997, PROTEIN SCI, V6, P698
  • [6] Superior performance in protein homology detection with the Blocks Database servers
    Henikoff, S
    Pietrokovski, S
    Henikoff, JG
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (01) : 309 - 312
  • [7] AUTOMATED ASSEMBLY OF PROTEIN BLOCKS FOR DATABASE SEARCHING
    HENIKOFF, S
    HENIKOFF, JG
    [J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (23) : 6565 - 6572
  • [8] HENIKOFF S, 1995, GENE, V163, P17
  • [9] Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences
    Rose, TM
    Schultz, ER
    Henikoff, JG
    Pietrokovski, S
    McCallum, CM
    Henikoff, S
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (07) : 1628 - 1635
  • [10] SEQUENCE LOGOS - A NEW WAY TO DISPLAY CONSENSUS SEQUENCES
    SCHNEIDER, TD
    STEPHENS, RM
    [J]. NUCLEIC ACIDS RESEARCH, 1990, 18 (20) : 6097 - 6100