Synaptic plasticity and nicotine addiction

被引：214

作者：

Dani, JA ^{[1
]}

Ji, DY ^{[1
]}

Zhou, FM ^{[1
]}

机构：

[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA

来源：

NEURON | 2001年 / 31卷 / 03期

关键词：

D O I：

10.1016/S0896-6273(01)00379-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nicotine, the main addictive component of tobacco, activates and desensitizes nicotinic acetylcholine receptors (nAChRs). In that way, nicotine alters normal nicotinic cholinergic functions. Among the myriad of psychopharmacological effects that underlie the addiction process, nicotine influences nAChR participation in synaptic plasticity. This influence has particular importance in the mesocorticolimbic dopamine system, which serves during the reinforcement of rewarding behaviors.

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收藏

页码：349 / 352

页数：4

相关论文

共 21 条

[1] Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity [J].

Albuquerque, EX ;

Pereira, EFR ;

Alkondon, M ;

Schrattenholz, A ;

Maelicke, A .

JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH, 1997, 17 (1-3) :243-266

[2] The putative role of extra-synaptic mesolimbic dopamine in the neurobiology of nicotine dependence [J].

Balfour, DJK ;

Wright, AE ;

Benwell, MEM ;

Birrell, CE .

BEHAVIOURAL BRAIN RESEARCH, 2000, 113 (1-2) :73-83

[3] Addiction, dopamine, and the molecular mechanisms of memory [J].

Berke, JD ;

Hyman, SE .

NEURON, 2000, 25 (03) :515-532

[4] Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function [J].

Buisson, B ;

Bertrand, D .

JOURNAL OF NEUROSCIENCE, 2001, 21 (06) :1819-1829

[5] Brain nicotinic receptors:: structure and regulation, role in learning and reinforcement [J].

Changeux, JP ;

Bertrand, D ;

Corringer, PJ ;

Dehaene, S ;

Edelstein, S ;

Léna, C ;

Le Novère, N ;

Marubio, L ;

Picciotto, M ;

Zoli, M .

BRAIN RESEARCH REVIEWS, 1998, 26 (2-3) :198-216

[6]

Corrigall W A, 1999, Nicotine Tob Res, V1, P11, DOI 10.1080/14622299050011121

[7] Molecular and cellular aspects of nicotine abuse [J].

Dani, JA ;

Heinemann, S .

NEURON, 1996, 16 (05) :905-908

[8] Overview of nicotinic receptors and their roles in the central nervous system [J].

Dani, JA .

BIOLOGICAL PSYCHIATRY, 2001, 49 (03) :166-174

[9] Role of dopamine in the behavioural actions of nicotine related to addiction [J].

Di Chiara, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 393 (1-3) :295-314

[10] Dramatic decreases in brain reward function during nicotine withdrawal [J].

Epping-Jordan, MP ;

Watkins, SS ;

Koob, GF ;

Markou, A .

NATURE, 1998, 393 (6680) :76-79