Genome-wide scan for Parkinson's disease:: The GenePD study

被引：62

作者：

DeStefano, AL

Golbe, LI

Mark, MH

Lazzarini, AM

Maher, NE

Saint-Hilaire, M

Feldman, RG

Guttman, M

Watts, RL

Suchowersky, O

Lafontaine, AL

Labelle, N

Lew, MF

Waters, CH

Growdon, JH

Singer, C

Currie, LJ

Wooten, GF

Vieregge, P

Pramstaller, PP

Klein, C

Hubble, JP

Stacy, M

Montgomery, E

MacDonald, ME

Gusella, JF

Myers, RH

机构：

[1] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Dept Epidemiol & Biostat, Boston, MA 02118 USA

[3] Boston Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Boston, MA 02118 USA

[4] Boston Univ, Sch Publ Hlth, Dept Neurol, Boston, MA 02118 USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Boston, MA USA

[6] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08903 USA

[7] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA

[8] Univ So Calif, Dept Neurol, Los Angeles, CA USA

[9] Univ Miami, Dept Neurol, Coral Gables, FL 33124 USA

[10] Univ Virginia, Hlth Syst, Dept Neurol, Charlottesville, VA USA

[11] Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA

[12] Barrow Clin, Dept Neurol, Phoenix, AZ USA

[13] Cleveland Clin Fdn, Dept Neurol, Cleveland, OH 44195 USA

[14] Cleveland Clin Fdn, Dept Neurosci, Cleveland, OH 44195 USA

[15] Med Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

[16] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[17] Univ Calgary, Dept Clin Neurosci, Calgary, AB T2N 1N4, Canada

[18] Univ Calgary, Dept Med Genet, Calgary, AB T2N 1N4, Canada

来源：

NEUROLOGY | 2001年 / 57卷 / 06期

关键词：

D O I：

10.1212/WNL.57.6.1124

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine P-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

引用

页码：1124 / 1126

页数：3

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