Finding the missing links in EGFR

被引：23

作者：

Bessman, Nicholas J. ^{[1
,2
]}

Lemmon, Mark A. ^{[1
,2
]}

机构：

[1] Univ Penn, Perelman Sch Med, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Grad Grp Biochem & Mol Biophys, Philadelphia, PA 19104 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2012年 / 19卷 / 01期

关键词：

GROWTH-FACTOR RECEPTOR; NEGATIVE COOPERATIVITY; STRUCTURAL BASIS; LIGAND-BINDING; KINASE DOMAIN; LUNG-CANCER; ACTIVATION; INHIBITION; MUTATIONS; INSIGHTS;

D O I：

10.1038/nsmb.2221

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural studies of the epidermal growth factor receptor ( EGFR) have advanced greatly in recent years, but they have used a 'divide-and-conquer' approach for independent study of the intracellular and extracellular regions. Several recent papers provide important new perspectives on 'undivided' EGFR and describe the initial steps in reconstructing signaling behavior of the intact receptor.

引用

页码：1 / 3

页数：3

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