Reduced Candida glabrata susceptibility secondary to an FKS1 mutation developed during Candidemia treatment

被引：87

作者：

Cleary, John D. ^{[1
,2
]}

Garcia-Effron, Guillermo ^{[3
]}

Chapman, Stanley W. ^{[1
,2
]}

Perlin, David S. ^{[3
]}

机构：

[1] Univ Mississippi, Mycot Res Ctr, Sch Pharm, Jackson, MS 39216 USA

[2] Univ Mississippi, Mycot Res Ctr, Sch Med, Jackson, MS 39216 USA

[3] UMDNJ New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 06期

关键词：

D O I：

10.1128/AAC.01568-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.

引用

页码：2263 / 2265

页数：3

共 16 条

[1] Acquired resistance to echinocandins in Candida albicans:: case report and review [J].

Baixench, Marie-Therese ;

Aoun, Naji ;

Desnos-Ollivier, Marie ;

Garcia-Hermoso, Dea ;

Bretagne, Stephane ;

Ramires, Sandrine ;

Piketty, Christophe ;

Dannaoui, Eric .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (06) :1076-1083

[2] Multilocus sequence typing of Candida glabrata reveals geographically enriched clades [J].

Dodgson, AR ;

Pujol, C ;

Denning, DW ;

Soll, DR ;

Fox, AJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (12) :5709-5717

[3]

ERNST EJ, 2006, 18 INT C ANT AG CHEM

[4] Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy [J].

Hakki, Morgan ;

Staab, Janet F. ;

Marr, Meren A. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (07) :2522-2524

[5]

Johnson MD, 2003, EXPERT OPIN PHARMACO, V4, P807, DOI 10.1517/14656566.4.5.807

[6] Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase [J].

Kahn, Jennifer Nielsen ;

Garcia-Effron, Guillermo ;

Hsu, Ming-Jo ;

Park, Steven ;

Marr, Kieren A. ;

Perlin, David S. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (05) :1876-1878

[7] Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility [J].

Katiyar, Santosh ;

Pfaller, Michael ;

Edlind, Thomas .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (08) :2892-2894

[8] Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient [J].

Krogh-Madsen, M ;

Arendrup, MC ;

Heslet, L ;

Knudsen, JD .

CLINICAL INFECTIOUS DISEASES, 2006, 42 (07) :938-944

[9] Progressive loss of echinocandin activity following prolonged use for treatment of Candida albicans oesophagitis [J].

Laverdière, M ;

Lalonde, RG ;

Baril, JG ;

Sheppard, DC ;

Park, S ;

Perlin, DS .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2006, 57 (04) :705-708

[10] Progressive esophagitis caused by Candida albicans with reduced susceptibility to caspofungin [J].

Miller, CD ;

Lomaestro, BW ;

Park, S ;

Perlin, DS .

PHARMACOTHERAPY, 2006, 26 (06) :877-880

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