Operant conditioning of H-reflex increase in spinal cord-injured rats

被引:29
作者
Chen, XY
Wolpaw, JR
Jakeman, LB
Stokes, BT
机构
[1] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Albany, NY 12201 USA
[2] SUNY Albany, Albany, NY 12222 USA
[3] Ohio State Univ, Dept Physiol, Columbus, OH 43210 USA
关键词
H-reflex; operant conditioning; plasticity; rat; soleus muscle; spinal cord injury;
D O I
10.1089/neu.1999.16.175
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Operant conditioning of the spinal stretch reflex or its electrical analog, the H-reflex, is a new model for exploring the mechanisms of long-term supraspinal control over spinal cord function. Primates and rats can gradually increase (HRup conditioning mode) or decrease (HRdown conditioning mode) the H-reflex when reward is based on H-reflex amplitude. An earlier study indicated that HRdown conditioning of the soleus H-reflex in rats is impaired following contusion injury to thoracic spinal cord. The extent of impairment was correlated with the percent of white matter lost at the injury site. The present study investigated the effects of spinal cord injury on HRup conditioning. Soleus H-reflexes were elicited and recorded with chronically implanted electrodes from 14 rats that had been subjected to calibrated contusion injuries to the spinal cord at T8, At the lesion epicenter, 12-39% of the white matter remained. After control-mode data were collected, each rat was exposed to the HRup conditioning mode for 50 days. Final H-reflex amplitudes after HRup conditioning averaged 112% (+/-22% SD) of control, This value was significantly smaller than that for 13 normal rats exposed to HRup conditioning, in which final amplitude averaged 153% (+/-51%) SD of control. As previously reported for HRdown conditioning after spinal cord injury, success was inversely correlated with the severity of the injury as assessed by white matter preservation and by time to return of bladder function, HRup and HRdown conditioning are similarly sensitive to injury, These results further demonstrate that H-reflex conditioning is a sensitive measure of the long-term effects of injury on supraspinal control over spinal cord functions and could prove a valuable measure of therapeutic efficacy.
引用
收藏
页码:175 / 186
页数:12
相关论文
共 62 条
[1]  
Ashby P, 1975, Can J Neurol Sci, V2, P91
[2]  
Baldissera F, 1981, HDB PHYSL 1 1, VII, P509, DOI DOI 10.1002/CPHY.CP010212
[3]   CELLULAR MORPHOLOGY OF CHRONIC SPINAL-CORD INJURY IN THE CAT - ANALYSIS OF MYELINATED AXONS BY LINE-SAMPLING [J].
BLIGHT, AR .
NEUROSCIENCE, 1983, 10 (02) :521-&
[4]   MODULATION OF THE SOLEUS H-REFLEX DURING PEDALING IN NORMAL HUMANS AND IN PATIENTS WITH SPINAL SPASTICITY [J].
BOORMAN, G ;
BECKER, WJ ;
MORRICE, BL ;
LEE, RG .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1992, 55 (12) :1150-1156
[5]   Three-Dimensional Computer-Assisted Analysis of Graded Contusion Lesions in the Spinal Cord of the Rat [J].
Bresnahan, Jacqueline C. ;
Beattie, Michael S. ;
Stokes, Bradford T. ;
Conway, Kevin M. .
JOURNAL OF NEUROTRAUMA, 1991, 8 (02) :91-101
[6]   A BEHAVIORAL AND ANATOMICAL ANALYSIS OF SPINAL-CORD INJURY PRODUCED BY A FEEDBACK-CONTROLLED IMPACTION DEVICE [J].
BRESNAHAN, JC ;
BEATTIE, MS ;
TODD, FD ;
NOYES, DH .
EXPERIMENTAL NEUROLOGY, 1987, 95 (03) :548-570
[7]  
BROWN WF, 1984, PHYSL TECHNICAL BASI, P144
[8]  
BURKE RE, 1978, HDB PHYSL NERVOU 2 I, V2, P877
[9]   EVIDENCE THAT ALTERATIONS IN PRESYNAPTIC INHIBITION CONTRIBUTE TO SEGMENTAL HYPOEXCITABILITY AND HYPEREXCITABILITY AFTER SPINAL-CORD INJURY IN MAN [J].
CALANCIE, B ;
BROTON, JG ;
KLOSE, KJ ;
TRAAD, M ;
DIFINI, J ;
AYYAR, DR .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1993, 89 (03) :177-186
[10]   MOTONEURON PLASTICITY UNDERLYING OPERANTLY CONDITIONED DECREASE IN PRIMATE H-REFLEX [J].
CARP, JS ;
WOLPAW, JR .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (01) :431-442