Cortical responsiveness during inner speech in schizophrenia: An event-related potential study

被引:58
作者
Ford, JM [1 ]
Mathalon, DH
Kalba, S
Whitfield, S
Faustman, WO
Roth, WT
机构
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Psychiat Serv, Palo Alto, CA USA
[3] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA
[4] Vet Affairs W Haven Hlth Care Syst, Psychiat Serv, W Haven, CT USA
关键词
D O I
10.1176/appi.ajp.158.11.1914
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The study assessed the effects of inner speech on auditory cortical responsiveness in schizophrenia. Method: Comparison subjects (N=15) and patients with schizophrenia (N=15) were presented with acoustic and visual stimuli during three conditions: while subjects were silent, when spontaneous inner speech might occur; during directed inner speech, while subjects repeated a statement silently to themselves; and while subjects listened to recorded speech. N1 event-related potentials were recorded during the three conditions. Results: N1 event-related potentials elicited by acoustic stimuli, but not by visual stimuli, were lower during directed inner speech than during the silent baseline condition in the comparison subjects but not in the patients. Conclusions: Abnormal auditory cortical responsiveness to inner speech in patients with schizophrenia may be a sign of corollary discharge dysfunction, which may potentially cause misattribution of inner speech to external voices.
引用
收藏
页码:1914 / 1916
页数:3
相关论文
共 9 条
[1]  
Andreasen N.C., 1983, SCALE ASSESSMENT POS
[2]   ACOUSTIC RELATIONS OF HUMAN VERTEX POTENTIAL [J].
DAVIS, H ;
ZERLIN, S .
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, 1966, 39 (01) :109-&
[3]   Activation of Heschl's Gyrus during auditory hallucinations [J].
Dierks, T ;
Linden, DEJ ;
Jandl, M ;
Formisano, E ;
Goebel, R ;
Lanfermann, H ;
Singer, W .
NEURON, 1999, 22 (03) :615-621
[4]   EFFERENCE COPY AND COROLLARY DISCHARGE - IMPLICATIONS FOR THINKING AND ITS DISORDERS [J].
FEINBERG, I .
SCHIZOPHRENIA BULLETIN, 1978, 4 (04) :636-640
[5]  
FORD JM, IN PRESS BIOL PSYCHI
[7]  
OVERALL JE, 1962, PSYCHOL REP, V10, P799
[8]   Functional anatomy of auditory verbal imagery in schizophrenic patients with auditory hallucinations [J].
Shergill, SS ;
Bullmore, E ;
Simmons, A ;
Murray, R ;
McGuire, P .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (10) :1691-1693
[9]   A functional study of auditory verbal imagery [J].
Shergill, SS ;
Bullmore, ET ;
Brammer, MJ ;
Williams, SCR ;
Murray, RM ;
McGuire, PK .
PSYCHOLOGICAL MEDICINE, 2001, 31 (02) :241-253