Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma:: Promoter hypermethylation with clinical correlation in 100 cases

被引：86

作者：

Ai, LB

Quynh, NV

Zuo, CL

Li, LW

Ling, WH

Suen, JY

Hanna, E

Brown, KD

Fan, CY

机构：

[1] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72205 USA

[2] John L McClellan Mem Vet Adm Med Ctr, Little Rock, AR 72205 USA

[3] Univ Arkansas Med Sci, Dept Otolaryngol, Little Rock, AR 72205 USA

[4] Sun Yat Sen Univ, Coll Publ Hlth, Guangzhou, Peoples R China

[5] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA

[6] Louisiana State Univ, Hlth Sci Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70112 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2004年 / 13卷 / 01期

关键词：

D O I：

10.1158/1055-9965.EPI-082-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Ataxia-telangiectasia-mutated (ATM) gene product is a well-characterized tumor suppressor that plays a key role in maintenance of genomic stability. We have recently documented that the ATM promoter is a target for epigenetic silencing in cultured tumor cells. Here we show that aberrant methylation of the ATM promoter occurs in a significant percentage (25%) of head and neck squamous cell carcinomas. The presence or methylated ATM promoter shows a statistically significant correlation with an earlier age of initial diagnosis and decreased overall survival, particularly in early-stage tumors. These findings indicate that ATM promoter hypermethylation occurs in head and neck squamous cell carcinoma, and this feature is a potentially useful prognostic marker in this tumor type.

引用

页码：150 / 156

页数：7

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