piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

被引：230

作者：

Cheng, Jia ^{[1
]}

Deng, Hongxia ^{[1
]}

Xiao, Bingxiu ^{[1
]}

Zhou, Hui ^{[1
]}

Zhou, Fei ^{[1
]}

Shen, Zhisen ^{[1
,2
]}

Guo, Junming ^{[1
]}

机构：

[1] Ningbo Univ, Sch Med, Ningbo 315211, Zhejiang, Peoples R China

[2] Ningbo Univ, Sch Med, Affiliated Lihuili Hosp, Ningbo 315040, Zhejiang, Peoples R China

来源：

CANCER LETTERS | 2012年 / 315卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PiRNA; Non-coding RNA; Carcinogenesis; Gastric cancer; HIWI GENE; EXPRESSION; MICRORNA; PIWI; MECHANISM; CARCINOMA; PIRNAS; RISK;

D O I：

10.1016/j.canlet.2011.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：12 / 17

页数：6

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