Novel spermine-based cationic gemini surfactants for gene delivery

被引:68
作者
Ronsin, G
Perrin, C
Guédat, P
Kremer, A
Camilleri, P
Kirby, AJ
机构
[1] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England
[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England
关键词
D O I
10.1039/b105936j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two types of spermine-based gemini surfactants have been synthesised; structure-activity studies have shown one type to be far superior in gene transection than the other.
引用
收藏
页码:2234 / 2235
页数:2
相关论文
共 5 条
[1]   EFFICIENT GENE-TRANSFER INTO MAMMALIAN PRIMARY ENDOCRINE-CELLS WITH LIPOPOLYAMINE-COATED DNA [J].
BEHR, JP ;
DEMENEIX, B ;
LOEFFLER, JP ;
MUTUL, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (18) :6982-6986
[2]   Potentiation of cationic liposome-mediated gene delivery by polycations [J].
Gao, X ;
Huang, L .
BIOCHEMISTRY, 1996, 35 (03) :1027-1036
[3]   A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA [J].
Lewis, JG ;
Lin, KY ;
Kothavale, A ;
Flanagan, WM ;
Matteucci, MD ;
DePrince, RB ;
Mook, RA ;
Hendren, RW ;
Wagner, RW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (08) :3176-3181
[4]  
MCGREGGOR C, IN PRESS J AM CHEM S
[5]  
99140451