Ketamine as a Novel Antidepressant: From Synapse to Behavior

被引：127

作者：

Murrough, J. W. ^{[1
,2
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机构：

[1] Mt Sinai Sch Med, Dept Psychiat, Mood & Anxiety Disorders Program, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Neurosci, New York, NY USA

[3] Mt Sinai Sch Med, Friedman Brain Inst, New York, NY USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2012年 / 91卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D-ASPARTATE ANTAGONIST; NMDA RECEPTOR BLOCKADE; TREATMENT-RESISTANT DEPRESSION; CEREBRAL-BLOOD-FLOW; PREFRONTAL CORTEX; TERM OUTCOMES; HUMANS; METABOLISM; GLUTAMATE; DISORDER;

D O I：

10.1038/clpt.2011.244

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recent reports of a rapid antidepressant effect of the glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine, even in treatment-resistant populations, have spurred translational therapeutic and neuroscience research aimed at elucidating ketamine's mechanism of action. This article provides a concise overview of research findings that pertain to the effects of low-dose ketamine at the cellular, neurocircuitry, and behavioral levels and describes an integrated model of the action of ketamine in the treatment of depression.

引用

页码：303 / 309

页数：7

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