The Suppressor-mutator element and the evolutionary riddle of transposons

被引：18

作者：

Fedoroff, NV

机构：

[1] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

[2] Penn State Univ, Inst Biotechnol, University Pk, PA 16802 USA

来源：

GENES TO CELLS | 1999年 / 4卷 / 01期

关键词：

D O I：

10.1046/j.1365-2443.1999.00233.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review focuses on the epigenetic control of the maize Suppressor-mutator (Spm) transposon and the evolutionary origin of epigenetic mechanisms. Methylation of the Spm promoter prevents transcription and transposition, and the methylation of the adjacent GC-rich sequence renders the inactive state heritable. Spm encodes an epigenetic activator, TnpA, one of the two Spm-encoded transposition proteins. TnpA can reactivate an inactive, methylated Spm both transiently and heritably, and it is also a transcriptional repressor of the unmethylated Spm promoter. Features common to epigenetic mechanisms in general suggest that they originated as a means of decreasing the recombinogenicity of duplicated sequences.

引用

收藏

页码：11 / 19

页数：9

相关论文

共 99 条

[1] TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA [J].

ANDERSON, RP ;

ROTH, JR .

ANNUAL REVIEW OF MICROBIOLOGY, 1977, 31 :473-505

[2] EPIGENETIC REPEAT-INDUCED GENE SILENCING (RIGS) IN ARABIDOPSIS [J].

ASSAAD, FF ;

TUCKER, KL ;

SIGNER, ER .

PLANT MOLECULAR BIOLOGY, 1993, 22 (06) :1067-1085

[3] MOLECULAR MECHANISMS IN THE DEVELOPMENTAL REGULATION OF THE MAIZE SUPPRESSOR-MUTATOR TRANSPOSABLE ELEMENT [J].

BANKS, JA ;

MASSON, P ;

FEDOROFF, N .

GENES & DEVELOPMENT, 1988, 2 (11) :1364-1380

[4] The unified grass genome: Synergy in synteny [J].

Bennetzen, JL ;

Freeling, M .

GENOME RESEARCH, 1997, 7 (04) :301-306

[5] Replicational model for DNA recombination between direct repeats [J].

Bi, X ;

Liu, LF .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 256 (05) :849-858

[6] DNA rearrangement mediated by inverted repeats [J].

Bi, X ;

Liu, LF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (02) :819-823

[7] PARAMUTATION AT THE R-LOCUS IN MAIZE [J].

BRINK, RA .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1958, 23 :379-391

[8] Mobile elements inserted in the distant past have taken on important functions [J].

Britten, RJ .

GENE, 1997, 205 (1-2) :177-182

[9] DNA sequence insertion and evolutionary variation in gene regulation [J].

Britten, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9374-9377

[10] Epigenetic silencing of a foreign gene in nuclear transformants of Chlamydomonas [J].

Cerutti, H ;

Johnson, AM ;

Gillham, NW ;

Boynton, JE .

PLANT CELL, 1997, 9 (06) :925-945

← 1 2 3 4 5 6 7 8 9 10 →