Polymorphisms in the Gene That Encodes the Iron Transport Protein Ferroportin 1 Influence Susceptibility to Tuberculosis

被引：10

作者：

Baker, Meghan A. ^{[1
,2
]}

Wilson, Douglas ^{[3
]}

Wallengren, Kristina ^{[1
,4
]}

Sandgren, Andreas ^{[1
]}

Iartchouk, Oleg ^{[5
]}

Broodie, Nisha ^{[6
]}

Goonesekera, Sunali D. ^{[1
]}

Sabeti, Pardis C. ^{[7
,8
]}

Murray, Megan B. ^{[1
,2
,9
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Massachusetts Gen Hosp, Dept Med, Div Infect Dis, Boston, MA 02114 USA

[3] Univ KwaZulu Natal, Dept Med, Edendale Hosp, Pietermaritzburg, South Africa

[4] Univ KwaZulu Natal, KwaZulu Natal Res Inst TB & HIV, Durban, South Africa

[5] Harvard Univ, Sch Med, Partners Healthcare Ctr Genet & Genom, Boston, MA 02115 USA

[6] Columbia Univ Coll Phys & Surg, New York, NY 10032 USA

[7] Harvard Univ, Dept Organism & Evolutionary Biol, Ctr Syst Biol, Cambridge, MA 02138 USA

[8] Broad Inst MIT & Harvard, Cambridge, MA USA

[9] Brigham & Womens Hosp, Dept Med, Div Global Hlth Equ, Boston, MA 02115 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 07期

关键词：

MYCOBACTERIUM-TUBERCULOSIS; AFRICAN-AMERICANS; OVERLOAD; ASSOCIATION; MUTATION;

D O I：

10.1093/infdis/jis026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Background. We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis. Methods. We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variables among 98 tuberculosis patients and 125 controls in Kwazulu-Natal, South Africa. Results. Four SLC40A1 single-nucleotide polymorphisms (SNPs) were associated with an increased risk of tuberculosis and 1 SNP with reduced risk. We also found a gene-environment interaction for 4 nonexonic SNPs and iron intake. Conclusions. This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1.

引用

页码：1043 / 1047

页数：5

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