Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

被引：404

作者：

Saburi, Sakura ^{[1
]}

Hester, Ian ^{[1
]}

Fischer, Evelyne ^{[2
]}

Pontoglio, Marco ^{[2
]}

Eremina, Vera ^{[1
]}

Gessler, Manfred ^{[3
]}

Quaggin, Sue E. ^{[1
,4
]}

Harrison, Robert ^{[5
]}

Mount, Richard ^{[5
]}

McNeill, Helen ^{[1
,6
]}

机构：

[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[2] Ctr Natl Rech Sci URA 2578, Dept Dev Biol, Gene Express Dev & Dis Lab, Inst Pasteur, Paris, France

[3] Univ Wurzburg, Theodor Boveri Inst, D-97074 Wurzburg, Germany

[4] St Michaels Hosp, Toronto, ON M5G 1X5, Canada

[5] Hosp Sick Children, Toronto, ON M5G 1X8, Canada

[6] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 1X5, Canada

来源：

NATURE GENETICS | 2008年 / 40卷 / 08期

关键词：

D O I：

10.1038/ng.179

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Tissue organization in Drosophila is regulated by the core planar cell polarity (PCP) proteins Frizzled, Dishevelled, Prickle, Van Gogh and Flamingo. Core PCP proteins are conserved in mammals and function in mammalian tissue organization. Recent studies have identified another group of Drosophila PCP proteins, consisting of the protocadherins Fat and Dachsous (Ds) and the transmembrane protein Four-jointed (Fj). In Drosophila, Fat represses fj transcription, and Ds represses Fat activity in PCP. Here we show that Fat4 is an essential gene that has a key role in vertebrate PCP. Loss of Fat4 disrupts oriented cell divisions and tubule elongation during kidney development, leading to cystic kidney disease. Fat4 genetically interacts with the PCP genes Vangl2 and Fjx1 in cyst formation. In addition, Fat4 represses Fjx1 expression, indicating that Fat signaling is conserved. Together, these data suggest that Fat4 regulates vertebrate PCP and that loss of PCP signaling may underlie some cystic diseases in humans.

引用

页码：1010 / 1015

页数：6

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