TREMs in Alzheimer's disease: Genetic and clinical investigations

被引：18

作者：

Cheng, Jia ^{[1
]}

Guo, XiaoFeng ^{[1
]}

Zhang, Tian ^{[1
]}

Zhong, Li ^{[2
]}

Bu, GuoJun ^{[2
,3
]}

Chen, XiaoFen ^{[2
]}

机构：

[1] Xiamen Univ, Zhongshan Hosp, Xiamen, Fujian, Peoples R China

[2] Xiamen Univ, Inst Neurosci, Coll Med, Fujian Prov Key Lab Neurodegenerat Dis & Aging Re, Xiamen, Fujian, Peoples R China

[3] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

来源：

CLINICA CHIMICA ACTA | 2016年 / 463卷

关键词：

TREM2; Alzheimer's disease; TREML; sTREM2; Biomarker; Epigenetic; FLUID SOLUBLE TREM2; MOUSE MODEL; INCREASED RISK; TAU; VARIANTS; INFLAMMATION; MICE; ASSOCIATION; DEFICITS; BINDS;

D O I：

10.1016/j.cca.2016.10.022

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Triggering receptor expressed on myeloid cells (TREMs) receptors constitute a family modulators in human innate immunity system that encode by a gene cluster. Rare variants in TREM2 were reported to be associated with significant Alzheimer's disease (AD) risk. However, inconsistent results were also reported in some studies of Non-European descents. Recently, the other TREM family members are also considered to involve in AD and cerebrospinal fluid (CSF) soluble form of TREM2 (sTREM2) levels has also been associated with respond to progression of disease. In this review, we converged the data of genetic and clinical investigations to identify the clearer role of TREMs in AD. Here, comprehensively analyze of multidisciplinary fields highlights the contribution of TREMs locus to AD development. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：88 / 95

页数：8

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