Autocatalysis and the generation of self-replicating systems

From an initial naphthoyl based molecule to a high-affinity biphenyl carbazole replicator, and from a minimalist self-complementary structure to a formal bimolecular replication cycle, the development of a series of self-replicating systems is charted. Successes and failures along the way are noted, with insight into the molecular properties required to generate molecular replication. Characterization of the observed autocatalysis is detailed, confirming the catalytic role of molecular recognition in the various systems.