Self-assembled microarrays of attoliter molecular vessels

被引：194

作者：

Stamou, D ^{[1
]}

Duschl, C

Delamarche, E

Vogel, H

机构：

[1] Ecole Polytech Fed Lausanne, CHB, Inst Sci Biomol, CH-1015 Lausanne, Switzerland

[2] IBM Corp, Div Res, Zurich Res Lab, CH-8803 Ruschlikon, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 45期

关键词：

liposomes; microarrays; nanostructures; self-assembly; vesicles;

D O I：

10.1002/anie.200351866

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

High-density microarrays of attoliter volume elements can be created (see figure) within minutes in a parallel and effortless manner by using self-assembly of nanometer-size components based on biological recognition. These ultrasmall volumes allow localization of single molecules, screening for (bio)chemical properties, and assessing the performance of confined chemical reactions.

引用

页码：5580 / 5583

页数：4

共 29 条

[1] Adhesion-induced domain formation by interplay of long-range repulsion and short-range attraction force: A model membrane study [J].

Albersdorfer, A ;

Feder, T ;

Sackmann, E .

BIOPHYSICAL JOURNAL, 1997, 73 (01) :245-257

[2] Micromosaic immunoassays [J].

Bernard, A ;

Michel, B ;

Delamarche, E .

ANALYTICAL CHEMISTRY, 2001, 73 (01) :8-12

[3] KINETICS OF HYDROGEN-ION DIFFUSION ACROSS PHOSPHOLIPID VESICLE MEMBRANCES [J].

BIEGEL, CM ;

GOULD, JM .

BIOCHEMISTRY, 1981, 20 (12) :3474-3479

[4] Micropatterned immobilization of a G protein-coupled receptor and direct detection of G protein activation [J].

Bieri, C ;

Ernst, OP ;

Heyse, S ;

Hofmann, KP ;

Vogel, H .

NATURE BIOTECHNOLOGY, 1999, 17 (11) :1105-1108

[5] Probing single secretory vesicles with capillary electrophoresis [J].

Chiu, DT ;

Lillard, SJ ;

Scheller, RH ;

Zare, RN ;

Rodriguez-Cruz, SE ;

Williams, ER ;

Orwar, O ;

Sandberg, M ;

Lundqvist, JA .

SCIENCE, 1998, 279 (5354) :1190-1193

[6] Chemical transformations in individual ultrasmall biomimetic containers [J].

Chiu, DT ;

Wilson, CF ;

Ryttsén, F ;

Strömberg, A ;

Farre, C ;

Karlsson, A ;

Nordholm, S ;

Gaggar, A ;

Modi, BP ;

Moscho, A ;

Garza-López, RA ;

Orwar, O ;

Zare, RN .

SCIENCE, 1999, 283 (5409) :1892-1895

[7] Direct patterning of modified oligonucleotides on metals and insulators by dip-pen nanolithography [J].

Demers, LM ;

Ginger, DS ;

Park, SJ ;

Li, Z ;

Chung, SW ;

Mirkin, CA .

SCIENCE, 2002, 296 (5574) :1836-1838

[8] Studies of vesicle extrusion [J].

Frisken, BJ ;

Asman, C ;

Patty, PJ .

LANGMUIR, 2000, 16 (03) :928-933

[9]

Gennis R.B., 1989, BIOMEMBRANES MOL STR

[10] Chemical kinetics - Smaller, faster chemistry [J].

Jensen, K .

NATURE, 1998, 393 (6687) :735-+

← 1 2 3 →