Progressive multifocal leukoencephalopathy and CD4+T-lymphocytopenia in a patient with Sjogren syndrome

被引：15

作者：

Hayashi, Yuichi ^{[1
]}

Kimura, Akio ^{[1
]}

Kato, Shimon ^{[1
]}

Koumura, Akihiro ^{[1
]}

Sakurai, Takeo ^{[1
]}

Tanaka, Yuji ^{[1
]}

Hozumi, Isao ^{[1
]}

Sunden, Yuji ^{[2
,3
]}

Orba, Yasuko ^{[2
]}

Sawa, Hirofumi ^{[2
,3
]}

Takahashi, Hitoshi ^{[4
]}

Inuzuka, Takashi ^{[1
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Neurol & Geriatr, Gifu 5011194, Japan

[2] Hokkaido Univ, Res Ctr Zoonosis Control, Dept Mol Pathobiol, Sapporo, Hokkaido, Japan

[3] 21st Century COE Program Zoonosis Control, Sapporo, Hokkaido, Japan

[4] Niigata Univ, Brain Res Inst, Dept Pathol, Niigata, Japan

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2008年 / 268卷 / 1-2期

关键词：

JC virus; progressive multifocal leukoencephalopathy; Sjogren syndrome; CD4+T-lymphocytopenia; I-123-IMP-SPECT; brain biopsy;

D O I：

10.1016/j.jns.2007.12.015

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report progressive multifocal leukoencephalopathy (PML) and CD4+ T-lymphocytopenia in a 71-year-old man with Sjogren syndrome (SjS). The patient was admitted to our hospital because of progressive dementia and gait disturbance. T2-weighted MR images showed high-intensity lesions in his left frontal white matter thalamus, cerebellum and brainstem. A pathological diagnosis of PML was made by brain biopsy. SjS is frequently accompanied with immunological complications; however, there are few reports on PML in patients with SjS. Recently, isolated CD4+ T-lymphocytopenia is reported to be one of the based immunological conditions associated with the development of PML. In the present case, CD4+ T-lymphocytopenia was also observed on admission, which is also associated with SjS. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：195 / 198

页数：4

共 18 条

[1]

Review of progressive multifocal leukoencephalopathy and natalizumab [J].

Aksamit, Allen J. .

NEUROLOGIST, 2006, 12 (06) :293-298

[2]

Idiopathic CD4(+) T lymphocytopenia presenting as progressive multifocal leukoencephalopathy: Case report [J].

Chikezie, PU ;

Greenberg, AL .

CLINICAL INFECTIOUS DISEASES, 1997, 24 (03) :526-527

[3]

Efficacy of 123N-isopropyl-p-[123I]-iodoamphetamine single photon emission computed tomography for the diagnosis of uveal malignant melanoma [J].

Goto, H ;

Usui, M ;

Ishii, I .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2001, 132 (06) :937-939

[4]

Haider S, 2000, Clin Infect Dis, V31, pE20, DOI 10.1086/318120

[5]

Disseminated cutaneous Kaposi sarcoma and progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia [J].

Inhoff, Oliver ;

Doerries, Kristina ;

Doerries, Ruediger ;

Scharf, Johann ;

Groden, Christoph ;

Goerdt, Sergij ;

Schadendorf, Dirk .

ARCHIVES OF DERMATOLOGY, 2007, 143 (05) :673-675

[6]

An unusual course of progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia [J].

Iwase, T ;

Ojika, K ;

Katada, E ;

Mitake, S ;

Nakazawa, H ;

Matsukawa, N ;

Otsuka, Y ;

Tsugu, Y ;

Kanai, H ;

Nakajima, K .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (06) :788-791

[7]

KIRTAVA Z, 1995, CLIN EXP RHEUMATOL, V13, P609

[8]

THE JC VIRUS-ANTIBODY RESPONSE IN SERUM AND CEREBROSPINAL-FLUID IN PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY [J].

KNOWLES, WA ;

LUXTON, RW ;

HAND, JF ;

GARDNER, SD ;

BROWN, DWG .

CLINICAL AND DIAGNOSTIC VIROLOGY, 1995, 4 (02) :183-194

[9]

Kokubun Norito, 2005, Rinsho Shinkeigaku, V45, P663

[10]

UNUSUAL UPTAKE AND RETENTION OF I-123 IMP IN BRAIN-TUMORS [J].

NAKANO, S ;

KINOSHITA, K ;

JINNOUCHI, S ;

HOSHI, H ;

WATANABE, K .

CLINICAL NUCLEAR MEDICINE, 1988, 13 (10) :742-747

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