Microglia in Pain: Detrimental and Protective Roles in Pathogenesis and Resolution of Pain

被引：687

作者：

Chen, Gang ^{[1
,2
]}

Zhang, Yu-Qiu ^{[3
,4
]}

Qadri, Yawar J. ^{[5
]}

Serhan, Charles N. ^{[6
,7
]}

Ji, Ru-Rong ^{[5
,8
]}

机构：

[1] Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, Nantong 226001, Jiangsu, Peoples R China

[2] Nantong Univ, Coinnovat Ctr Neuroregenerat, Minist Educ, Nantong 226001, Jiangsu, Peoples R China

[3] Fudan Univ, Collaborat Innovat Ctr Brain Sci, Inst Brain Sci, Inst Neurobiol, Shanghai 200032, Peoples R China

[4] Fudan Univ, Collaborat Innovat Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China

[5] Duke Univ, Med Ctr, Dept Anesthesiol, Ctr Translat Pain Med, Durham, NC 27710 USA

[6] Brigham & Womens Hosp, Dept Anesthesiol Perioperat & Pain Med, Hale Transformat Med, Ctr Expt Therapeut & Reperfus Injury, 75 Francis St, Boston, MA 02115 USA

[7] Harvard Med Sch, Boston, MA 02115 USA

[8] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

NEURON | 2018年 / 100卷 / 06期

关键词：

PERIPHERAL-NERVE INJURY; ACTIVATED PROTEIN-KINASE; SPINAL-CORD MICROGLIA; P38 MAP KINASE; RESOLVING LIPID MEDIATORS; LONG-TERM POTENTIATION; RECEPTOR UP-REGULATION; TOLL-LIKE RECEPTORS; NEUROPATHIC PAIN; DORSAL-HORN;

D O I：

10.1016/j.neuron.2018.11.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The previous decade has seen a rapid increase in microglial studies on pain, with a unique focus on microgliosis in the spinal cord after nerve injury and neuropathic pain. Numerous signaling molecules are altered in microglia and contribute to the pathogenesis of pain. Here, we discuss how microglial signaling regulates spinal cord synaptic plasticity in acute and chronic pain conditions with different degrees and variations of microgliosis. We highlight that microglial mediators such as pro- and anti-inflammatory cytokines are powerful neuromodulators that regulate synaptic transmission and pain via neuron-glial interactions. We also reveal an emerging role of microglia in the resolution of pain, in part via specialized pro-resolving mediators including resolvins, protectins, and maresins. We also discuss a possible role of microglia in chronic itch.

引用

页码：1292 / 1311

页数：20

共 236 条

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