Dealing with energy demand: the AMP activated protein kinase

被引：449

作者：

Kemp, BE

Mitchelhill, KI

Stapleton, D

Michell, BJ

Chen, ZP

Witters, LA

机构：

[1] St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia

[2] Dartmouth Med Sch, Dept Med, Endocrine Metab Div, Hanover, NH 03755 USA

[3] Dartmouth Med Sch, Dept Biochem, Endocrine Metab Div, Hanover, NH 03755 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(98)01340-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

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页码：22 / 25

页数：4

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