Immunological and virological effects of long term IL-2 therapy in HIV-1-infected patients

被引：28

作者：

Gougeon, ML

Rouzioux, C

Liberman, I

Burgard, M

Taoufik, Y

Viard, JP

Bouchenafa, K

Capitant, C

Delfraissy, JF

Levy, Y

机构：

[1] Inst Pasteur, Dept SIDA & Retrovirus, F-75724 Paris 15, France

[2] CHU Necker Enfants Malad, Serv Virol, F-75743 Paris 15, France

[3] CHU Necker Enfants Malad, Serv Immunol Clin, F-75743 Paris 15, France

[4] CHU Kremlin Bicetre, Serv Med Interne, Le Kremlin Bicetre, France

[5] INSERM SC10, F-94807 Villejuif, France

[6] Hop Henri Mondor, Serv Immunol Clin, F-94010 Creteil, France

来源：

AIDS | 2001年 / 15卷 / 13期

关键词：

D O I：

10.1097/00002030-200109070-00018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the long-term outcome of 27 HIV-infected patients treated for over 3 years with IL-2 and binucleoside analogues. These patients experienced a sustained increase in CD4 cells and a decrease of proviral DNA with infrequent IL-2 cycles. In three cases, virus could not be isolated from activated peripheral cells. A high frequency of HIV-1-specific memory CD4 T cells was found in the patients studied. IL-2 maintains specific effector cells and reduces the pool of infected cells in patients, albeit treated only with binucleosides.

引用

页码：1729 / 1731

页数：3

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