Management of Side Effects of Androgen Deprivation Therapy

被引：56

作者：

Grossmann, Mathis ^{[1
,2
]}

Zajac, Jeffrey D. ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Med Austin Hlth No Hlth, Heidelberg, Vic 3084, Australia

[2] Austin Hlth, Dept Endocrinol, Heidelberg, Vic 3084, Australia

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 03期

基金：

英国医学研究理事会;

关键词：

Androgen deprivation; Prostate cancer; Osteoporosis; Insulin resistance; Testosterone; NONMETASTATIC PROSTATE-CANCER; RANDOMIZED CONTROLLED-TRIAL; BONE-MINERAL DENSITY; QUALITY-OF-LIFE; ZOLEDRONIC ACID; CARDIOVASCULAR-DISEASE; FRACTURE RISK; HOT FLASHES; SUPPRESSION THERAPY; REPLACEMENT THERAPY;

D O I：

10.1016/j.ecl.2011.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Androgen deprivation therapy (ADT) is a major component of the contemporary management of prostate cancer. ADT's use is increasing rapidly. The side effects of this therapy include loss of bone mass and fractures, increase in fat mass, and worsening of insulin resistance, the metabolic syndrome, diabetes and cardiovascular risk, and anemia and loss of muscle. Neuropsychological and sexual symptoms are common. The impact of these side effects is often overlooked or underestimated in decisions about prostate cancer therapy. This review surveys the data relating to the side effects of ADT and provides recommendations regarding their minimization and management.

引用

页码：655 / +

页数：18

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