Allele-specific binding to the -308 single nucleotide polymorphism site in the tumour necrosis factor-alpha promoter

被引：30

作者：

Baseggio, L

Bartholin, L

Chantome, A

Charlot, C

Rimokh, R

Salles, G

机构：

[1] Univ Lyon 1, F-69365 Lyon, France

[2] Ctr Leon Berard, INSERM, U590, F-69373 Lyon, France

[3] Univ Bourgogne, INSERM, U517, Dijon, France

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 2004年 / 31卷 / 01期

关键词：

D O I：

10.1111/j.1365-2370.2004.00440.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Single nucleotide polymorphisms in the tumour necrosis factor alpha (TNF-alpha) promoter region may modulate TNF-alpha gene transcriptional activity by modifying the binding of transcription factors. Here we confirm that a specific DNA complex binds preferentially the variant TNF2 allele in various cell types and demonstrate that activating protein (AP)-2, myeloid zinc finger gene 1 (MZF-1) and Sp1 are not involved in this complex.

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页码：15 / 19

页数：5

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