Linking signalling pathways, thymic stroma integrity and autoimmunity

被引：49

作者：

Derbinski, J ^{[1
]}

Kyewski, B ^{[1
]}

机构：

[1] German Canc Res Ctr, Div Dev Immunol, Tumor Immunol Program, D-69120 Heidelberg, Germany

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 10期

关键词：

D O I：

10.1016/j.it.2005.07.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Medullary thymic epithelial cells (mTECs) are indispensable for self-tolerance to peripheral organs by virtue of their expression of a host of tissue-restricted self-antigens. The full extent of this promiscuous gene expression is confined to functionally mature mTECs. Consequently, any interference with signalling pathways directing the differentiation and/or proliferation of this mature subset will affect the scope of central tolerance and potentially predispose to autoimmunity. In a recent study, tumour necrosis factor receptor-associated factor 6 (TRAF6) has been identified as an essential component of a new signalling pathway directing mTEC development.

引用

页码：503 / 506

页数：4

共 17 条

[1] Dependence of self-tolerance on TRAF6-directed development of thymic stroma [J].

Akiyama, T ;

Maeda, S ;

Yamane, S ;

Ogino, K ;

Kasai, M ;

Kajiura, F ;

Matsumoto, M ;

Inoue, J .

SCIENCE, 2005, 308 (5719) :248-251

[2] Thymic medullary epithelial cell differentiation thymocyte emigration, and the control of autoimmunity require lymphoepithelial cross talk via LTβR [J].

Boehm, T ;

Scheu, S ;

Pfeffer, K ;

Bleul, CC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (05) :757-769

[3] Transcription of the RelB gene is regulated by NF-κB [J].

Bren, GD ;

Solan, NJ ;

Miyoshi, H ;

Pennington, KN ;

Pobst, LJ ;

Paya, CV .

ONCOGENE, 2001, 20 (53) :7722-7733

[4] EXPRESSION OF RELB IS REQUIRED FOR THE DEVELOPMENT OF THYMIC MEDULLA AND DENDRITIC CELLS [J].

BURKLY, L ;

HESSION, C ;

OGATA, L ;

REILLY, C ;

MARCONI, LA ;

OLSON, D ;

TIZARD, R ;

CATE, R ;

LO, D .

NATURE, 1995, 373 (6514) :531-536

[5] Lymphotoxin pathway directs thymic Aire expression [J].

Chin, RK ;

Lo, JC ;

Kim, O ;

Blink, SE ;

Christiansen, PA ;

Peterson, P ;

Wang, Y ;

Ware, C ;

Fu, YX .

NATURE IMMUNOLOGY, 2003, 4 (11) :1121-1127

[6] The signaling adaptors and pathways activated by TNF superfamily [J].

Dempsey, PW ;

Doyle, SE ;

He, JQ ;

Cheng, GH .

CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (3-4) :193-209

[7] Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels [J].

Derbinski, J ;

Gäbler, J ;

Brors, B ;

Tierling, S ;

Jonnakuty, S ;

Hergenhahn, M ;

Peltonen, L ;

Walter, J ;

Kyewski, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (01) :33-45

[8]

Heino M, 2000, EUR J IMMUNOL, V30, P1884, DOI 10.1002/1521-4141(200007)30:7<1884::AID-IMMU1884>3.0.CO

[9]

2-P

[10] Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions [J].

Jalukar, SV ;

Hostager, BS ;

Bishop, GA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (02) :623-630

← 1 2 →