Dystonia: an update on genetics and treatment

被引：6

作者：

Misbahuddin, A ^{[1
]}

Warner, TT ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Dept Clin Neurosci, London NW3 2PF, England

来源：

CURRENT OPINION IN NEUROLOGY | 2001年 / 14卷 / 04期

关键词：

D O I：

10.1097/00019052-200108000-00007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent years have seen many advances in our understanding of the genetics of the dystonias, with 13 loci identified to date. The DYT1 gene, which causes most cases of childhood-onset generalized primary dystonia, was cloned in 1997, and use of cell models has begun to unravel the role of its protein (torsinA) in both health and disease. Treatment of more severe dystonia has been a difficult area, with only limited success from medical therapies. Recently, there has been increasing interest in the use of globus pallidus deep brain stimulation and a number of reports have shown promising results. Curr Opin Neurol 14:471-475. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：471 / 475

页数：5

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