Corpus callosotomy

被引：149

作者：

Asadi-Pooya, Ali A. ^{[1
]}

Sharan, Ashwini ^{[2
]}

Nei, Maromi ^{[1
]}

Sperling, Michael R. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Comprehens Epilepsy Ctr, Dept Neurol, Philadelphia, PA 19107 USA

[2] Thomas Jefferson Univ, Dept Neurosurg, Philadelphia, PA 19107 USA

来源：

EPILEPSY & BEHAVIOR | 2008年 / 13卷 / 02期

关键词：

corpus callosum; callosotomy; effects; epilepsy; prognostic factors;

D O I：

10.1016/j.yebeh.2008.04.020

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Corpus callosotomy is a palliative surgical procedure that is suitable for some patients with intractable seizures who are not candidates for focal resective surgery. The rationale for this procedure is based on the hypothesis that the corpus callosum is a critical pathway for interhemispheric spread of epileptic activity. Efficacy and relatively low permanent morbidity in corpus callosotomy for medically intractable epilepsy have been demonstrated by more than six decades of experience. Callosotomy best ameliorates drop attacks (tonic and atomic seizures), though tonic-clonic, absence, and frontal lobe complex partial seizures often respond as well. In addition to seizure reduction, behavior and quality of life may improve. Hence, callosotomy is justified as a therapy for appropriate patients with intractable epilepsy. (c) 2008 Elsevier Inc. All rights reserved.

引用

收藏

页码：271 / 278

页数：8

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