Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naive Social Phobia Patients

被引：530

作者：

Bergamaschi, Mateus M. ^{[1
,2
,3
]}

Costa Queiroz, Regina Helena ^{[2
,3
]}

Nisihara Chagas, Marcos Hortes ^{[1
,3
]}

Gomes de Oliveira, Danielle Chaves ^{[1
,3
]}

De Martinis, Bruno Spinosa ^{[3
,4
]}

Kapczinski, Flavio ^{[3
,5
]}

Quevedo, Joao ^{[3
,6
]}

Roesler, Rafael ^{[3
,7
]}

Schroeder, Nadja ^{[3
,8
]}

Nardi, Antonio E. ^{[3
,9
]}

Martin-Santos, Rocio ^{[3
,10
]}

Cecilio Hallak, Jaime Eduardo ^{[1
,3
]}

Zuardi, Antonio Waldo ^{[1
,3
]}

Crippa, Jose Alexandre S. ^{[1
,3
]}

机构：

[1] Univ Sao Paulo, Dept Neurosci & Behav, Sch Med Ribeirao Preto, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Clin Toxicol & Food Sci Anal, Sch Pharmaceut Sci Ribeirao Preto, BR-05508 Sao Paulo, Brazil

[3] CNPq, Natl Inst Translat Med INCT TM, Brasilia, DF, Brazil

[4] Univ Sao Paulo, Dept Chem, Sch Philosophy Sci & Literature Ribeirao Preto, BR-14049 Ribeirao Preto, SP, Brazil

[5] Hosp Clin Porto Alegre, Bipolar Disorder Program, Porto Alegre, RS, Brazil

[6] Univ So Santa Catarina, Lab Neurosci, Hlth Sci Unit, Criciuma, SC, Brazil

[7] Univ Fed Rio Grande do Sul, Lab Mol Neuropharmacol, Dept Pharmacol, Inst Basic Hlth Sci, Porto Alegre, RS, Brazil

[8] Pontif Catholic Univ, Neurobiol & Dev Biol Lab, Sch Biosci, Porto Alegre, RS, Brazil

[9] Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, Brazil

[10] CIBERSAM, Dept Psychiat, Inst Neurosci, Hosp Clin,IDIBAPS, Barcelona, Spain

来源：

NEUROPSYCHOPHARMACOLOGY | 2011年 / 36卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

cannabidiol; CBD; anxiety; simulation of public speaking test; SPST; social anxiety disorder; MINI-SPIN; PERIAQUEDUCTAL GRAY; SCREENING TOOL; NEURAL BASIS; DELTA(9)-TETRAHYDROCANNABINOL; DISORDER; DELTA-9-TETRAHYDROCANNABINOL; EPIDEMIOLOGY; CANNABINOIDS; PHARMACOLOGY;

D O I：

10.1038/npp.2011.6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. Cannabidiol (CBD), one major non-psychotomimetic compound of the cannabis sativa plant, has shown anxiolytic effects both in humans and in animals. This preliminary study aimed to compare the effects of a simulation public speaking test (SPST) on healthy control (HC) patients and treatment-naive SAD patients who received a single dose of CBD or placebo. A total of 24 never-treated patients with SAD were allocated to receive either CBD (600 mg; n = 12) or placebo (placebo; n = 12) in a double-blind randomized design 1 h and a half before the test. The same number of HC (n = 12) performed the SPST without receiving any medication. Each volunteer participated in only one experimental session in a double-blind procedure. Subjective ratings on the Visual Analogue Mood Scale (VAMS) and Negative Self-Statement scale (SSPS-N) and physiological measures (blood pressure, heart rate, and skin conductance) were measured at six different time points during the SPST. The results were submitted to a repeated-measures analysis of variance. Pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech. The placebo group presented higher anxiety, cognitive impairment, discomfort, and alert levels when compared with the control group as assessed with the VAMS. The SSPS-N scores evidenced significant increases during the testing of placebo group that was almost abolished in the CBD group. No significant differences were observed between CBD and HC in SSPS-N scores or in the cognitive impairment, discomfort, and alert factors of VAMS. The increase in anxiety induced by the SPST on subjects with SAD was reduced with the use of CBD, resulting in a similar response as the HC. Neuropsychopharmacology (2011) 36, 1219-1226; doi: 10.1038/npp.2011.6; published online 9 February 2011

引用

页码：1219 / 1226

页数：8

共 45 条

[1] INTERACTIONS OF DELTA-1-TETRAHYDROCANNABINOL WITH CANNABINOL AND CANNABIDIOL FOLLOWING ORAL-ADMINISTRATION IN MAN - ASSAY OF CANNABINOL AND CANNABIDIOL BY MASS FRAGMENTOGRAPHY [J].