Neurosteroids and brain sexual differentiation

被引:45
作者
Schlinger, BA [1 ]
Soma, KK
London, SE
机构
[1] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Brain Res Inst, Neuroendocrinol Lab, Los Angeles, CA 90095 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
D O I
10.1016/S0166-2236(00)01855-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is new evidence that the brain of developing songbirds can synthesize estradiol de novo. In males, this neurally derived estrogen might masculinize a connection within the neural song system. These results challenge traditional concepts about mechanisms of brain sexual differentiation and reveal a significant function for neurosteroids.
引用
收藏
页码:429 / 431
页数:3
相关论文
共 20 条
[1]  
Adkins-Regan E., 1981, Neuroendocrinology of reproduction. Physiology and behavior., P159
[2]   SEX STEROID-LEVELS IN DEVELOPING AND ADULT MALE AND FEMALE ZEBRA FINCHES (POEPHILA-GUTTATA) [J].
ADKINSREGAN, E ;
ABDELNABI, M ;
MOBARAK, M ;
OTTINGER, MA .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1990, 78 (01) :93-109
[3]  
AGATE RJ, 2000, SOC NEUR ABSTR, V26, P594
[4]  
Arnold AP, 2000, SEXUAL DIFFERENTIATION OF THE BRAIN, P131
[5]   SEXUAL-DIFFERENTIATION OF BRAIN AND BEHAVIOR IN BIRDS [J].
BALTHAZART, J ;
BALL, GF .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1995, 6 (01) :21-29
[6]  
Baulieu E.E., 1999, NEUROSTEROIDS NEW RE
[7]   Neurosteroids: Biosynthesis and function of these novel neuromodulators [J].
Compagnone, NA ;
Mellon, SH .
FRONTIERS IN NEUROENDOCRINOLOGY, 2000, 21 (01) :1-56
[8]   The expression of the sex steroid-synthesizing enzymes CYP11A1, 3β-HSD, CYP17, and CYP19 in gonads and adrenals of adult and developing zebra finches [J].
Freking, F ;
Nazairians, T ;
Schlinger, BA .
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 2000, 119 (02) :140-151
[9]  
Gahr M, 1999, J NEUROSCI, V19, P2628
[10]   HORMONE-INDUCED SEXUAL-DIFFERENTIATION OF BRAIN AND BEHAVIOR IN ZEBRA FINCHES [J].
GURNEY, ME ;
KONISHI, M .
SCIENCE, 1980, 208 (4450) :1380-1383