Advantages of RGD peptides for directing cell association with biomaterials

被引：591

作者：

Bellis, Susan L. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Physiol & Biophys, Birmingham, AL 35294 USA

来源：

BIOMATERIALS | 2011年 / 32卷 / 18期

关键词：

RGD; Integrin; Extracellular matrix; Tissue regeneration; Cell adhesion; OSTEOBLAST-ADHESIVE PEPTIDES; COATED TITANIUM IMPLANTS; ADSORBED SERUM-PROTEINS; BONE-FORMATION; EXTRACELLULAR-MATRIX; FIBRINOGEN BINDING; INTEGRIN LIGANDS; CYTOSKELETAL ORGANIZATION; HYDROXYAPATITE SURFACES; CYCLIC PENTAPEPTIDES;

D O I：

10.1016/j.biomaterials.2011.02.029

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Despite many years of in vitro research confirming the effectiveness of RGD in promoting cell attachment to a wide variety of biomaterials, animal studies evaluating tissue responses to implanted RGD-functionalized substrates have yielded more variable results. The goals of this report are to present some of the reasons why cell culture studies may not always reliably predict in vivo responses, and more importantly, to highlight potential applications that may benefit from the use of RGD peptides. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4205 / 4210

页数：6

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