Feedback control of a biodynamical model of HIV-1

被引：75

作者：

Brandt, ME

Chen, GR

机构：

[1] Univ Texas, Hlth Sci Ctr, Sch Hlth Informat Sci, Neurosignal Anal Lab, Houston, TX 77030 USA

[2] Univ Houston, Dept Elect & Comp Engn, Houston, TX 77030 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2001年 / 48卷 / 07期

关键词：

antiretroviral therapy; feedback control; HIV infection; nonlinear modeling;

D O I：

10.1109/10.930900

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We describe a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. We demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. We also show how the immune system components can be bolstered against the virus through a feedback control approach.

引用

收藏

页码：754 / 759

页数：6

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