Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression

被引：91

作者：

Walker, JL ^{[1
]}

Assoian, RK ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

来源：

CANCER AND METASTASIS REVIEWS | 2005年 / 24卷 / 03期

关键词：

adhesion; signaling; cell cycle; growth factor receptor;

D O I：

10.1007/s10555-005-5130-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27(kip1). Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.

引用

页码：383 / 393

页数：11

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