Interleukin-17 contributes to cardiovascular diseases

被引：23

作者：

Ding, Hua-Sheng ^{[1
,2
]}

Yang, Jun ^{[1
,2
]}

Yang, Jian ^{[1
,2
]}

Ding, Jia-Wang ^{[1
,2
]}

Chen, Ping ^{[3
]}

Zhu, Ping ^{[4
]}

机构：

[1] China Three Gorges Univ, Inst Cardiovasc Dis, Yichang 443000, Hubei Province, Peoples R China

[2] China Three Gorges Univ, Dept Cardiol, Coll Clin Med Sci 1, Yichang 443000, Hubei Province, Peoples R China

[3] China Three Gorges Univ, Dept Emergency, Coll Clin Med Sci 1, Yichang 443000, Hubei Province, Peoples R China

[4] China Three Gorges Univ, Dept Nephrol, Coll Clin Med Sci 1, Yichang 443000, Hubei Province, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2012年 / 39卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Interleukin-17; T helper 17 cells; Inflammatary response; Cardiovascular diseases; CD4; T-CELLS; ISCHEMIA-REPERFUSION; IL-17; RECEPTOR; MURINE MODEL; EXPRESSION; LINEAGE; TH17; ATHEROSCLEROSIS; AUTOIMMUNE; GAMMA;

D O I：

10.1007/s11033-012-1580-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin (IL)-17 (also known as IL-17A), as the signature cytokine of the newly described T helper 17 (Th17) cell population, is the founding member of a new subclass of cytokines that have highly proinflammatory properties. Recently there is accumulating evidence that stipulates the involvement of IL-17 in the pathogenesis of cardiovascular diseases via amplifying the inflammation induced by other cytokines in synergistic interactions. The present review provides a summary of the potential roles of IL-17 in the context derived from both animal models and clinical settings in cardiovascular diseases, and perspectives for IL-17-targeted cytokine therapy.

引用

收藏

页码：7473 / 7478

页数：6

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