Statistical model of the hippocampal CA3 region -: I.: The single-cell module:: bursting model of the pyramidal cell

被引：15

作者：

Grobler, T ^{[1
]}

Barna, G ^{[1
]}

Érdi, P ^{[1
]}

机构：

[1] Hungarian Acad Sci, Res Inst Particle & Nucl Phys, KFKI, Dept Biophys, H-1525 Budapest, Hungary

来源：

BIOLOGICAL CYBERNETICS | 1998年 / 79卷 / 04期

关键词：

D O I：

10.1007/s004220050480

中图分类号：

TP3 [计算技术、计算机技术];

学科分类号：

0812 ;

摘要：

A model with intermediate complexity is introduced to reproduce the basic firing modes of the CA3 pyramidal cell. Our model consists of a single compartment, has two variables (membrane potential and internal calcium concentration), and involves two separate stages for interspike mechanisms and firing. Interspike dynamics is governed by voltage- and calcium-dependent ionic channels but no channel kinetics are provided. This model is suitable to be included in our statistical population model (Part II, following paper). Bifurcation analysis reveals that interspike dynamics rather than sodium firing has the dominant role in the control of bursting/nonbursting behavior.

引用

页码：301 / 308

页数：8

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