Lipase catalysed synthesis of optically enriched α-haloamides

被引：20

作者：

Azim, A

Sharma, SK

Olsen, CE

Parmar, VS ^{[1
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Royal Vet & Agr Univ, Dept Chem, DK-1871 Frederiksberg C, Copenhagen, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0968-0896(01)00006-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient lipase catalysed synthesis of optically enriched alpha -halogenated amides with concomitant optical enrichment of the starting alpha -haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1345 / 1348

页数：4

共 18 条

[1] MODEL DEPSIPEPTIDE DERIVATIVES FROM 2-BROMO-N-BENZYLISOBUTYRAMIDE [J].