Preparation of water-dispersible and biocompatible iron oxide nanoparticles for MRI agent

被引：17

作者：

Lee, Yun Tack ^{[1
]}

Woo, Kyoungja ^{[1
]}

Choi, Kyu-Sil ^{[2
]}

机构：

[1] Korea Inst Sci & Technol, Nanomat Res Ctr, Seoul 130650, South Korea

[2] Wonkwang Univ, Sch Med, Inst Radiol Imaging Sci, Jeonbuk 570749, South Korea

来源：

IEEE TRANSACTIONS ON NANOTECHNOLOGY | 2008年 / 7卷 / 02期

关键词：

dextran; MRI agent; SPION; surface modification;

D O I：

10.1109/TNANO.2007.909949

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Highly monodisperse superparamagnetic iron oxide nanoparticles (SPIONs, 7.5 nm gamma - Fe2O3) were synthesized by thermal decomposition of iron pentacarbonyl and consecutive aeration in organic medium. By treating with a small amount of iron pentacarbonyl, Fe-rich surface has been formed on SPION. Water-dispersible SPIONs (SPION-MPA) were prepared by Fe-S covalent conjugation between Fe-rich SPION and mercaptopropionic acid (MPA) and then, transformed to SPION - MPA - dextran composite by physical adsorption of biocompatible polymer dextran. The hydrodynamic diameter of SPION - MPA - dextran was in the range of 225 similar to 237 urn in water. MR contrast and spin-spin relaxation intensity of our SPION - MPA - dextran were similar to those of the commercial products, Ferridex and Resovist.

引用

页码：111 / 114

页数：4

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