Ion release from magnesium materials in physiological solutions under different oxygen tensions

被引：38

作者：

Feyerabend, Frank ^{[1
]}

Druecker, Heiko ^{[2
]}

Laipple, Daniel

Vogt, Carla ^{[2
]}

Stekker, Michael ^{[3
]}

Hort, Norbert

Willumeit, Regine ^{[1
]}

机构：

[1] Helmholtz Zentrum Geesthacht, Inst Mat Res, Dept Macromol Struct Res, D-21502 Geesthacht, Germany

[2] Leibniz Univ Hannover, Inst Inorgan Chem, D-30167 Hannover, Germany

[3] MeKo, D-31157 Sarstedt Hannover, Germany

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2012年 / 23卷 / 01期

关键词：

RARE-EARTH ALLOY; CORROSION; DEGRADATION; STENTS; CELLS;

D O I：

10.1007/s10856-011-4490-5

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Although magnesium as degradable biomaterial already showed clinical proof of concepts, the design of new alloys requires predictive in vitro methods, which are still lacking. Incubation under cell culture conditions to obtain "physiological" corrosion may be a solution. The aim of this study was to analyse the influence of different solutions, addition of proteins and of oxygen availability on the corrosion of different magnesium materials (pure Mg, WE43, and E11) with different surface finishing. Oxygen content in solution, pH, osmolality and ion release were determined. Corrosion led to a reduction of oxygen in solution. The influence of oxygen on pH was enhanced by proteins, while osmolality was not influenced. Magnesium ion release was solution-dependent and enhanced in the initial phase by proteins with delayed release of alloying elements. The main corrosion product formed was magnesium carbonate. Therefore, cell culture conditions are proposed as first step toward physiological corrosion.

引用

页码：9 / 24

页数：16

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