Fibrinogen heterogeneity: inherited and noninherited

被引：46

作者：

de Maat, MPM

Verschuur, M

机构：

[1] Erasmus Univ, Med Ctr, Dept Hematol, NL-3015 GE Rotterdam, Netherlands

[2] Leiden Univ, Ctr Med, Dept Hematol, NL-2300 RA Leiden, Netherlands

来源：

CURRENT OPINION IN HEMATOLOGY | 2005年 / 12卷 / 05期

关键词：

fibrinogen; fibrin structure; polymorphisms; splicing variants;

D O I：

10.1097/01.moh.0000169287.51594.3b

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Many noninherited variations have been described in fibrinogen and they may affect the different functions of fibrogen. Recent findings A number of the acquired variations in fibrinogen molecule, such as the conversion rate to fibrin and/or the characteristics of the fibrin clot. Also, genetic polymorphisms are known that can affect the function of the fibrinogen molecule. In addition, some other genetic variants are associated with plasma levels of fibrinogen and with the increase of fibrinogen levels during an acute-phase reaction. Summary In this review the authors discuss the noninherited and inherited variations of fibrinogen and the clinical implications (e.g. when determining the risk of cardiovascular disease).

引用

页码：377 / 383

页数：7

共 80 条

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