A stereoselective synthesis of dl-threo-methylphenidate:: Preparation and biological evaluation of novel analogues

被引：50

作者：

Axten, JM

Krim, L

Kung, HF ^{[1
]}

Winkler, JD

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1998年 / 63卷 / 26期

关键词：

D O I：

10.1021/jo982214t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：9628 / 9629

页数：2

共 14 条

[1] SELECTIVE DOPAMINE TRANSPORTER INHIBITION BY COCAINE ANALOGS [J].

BOJA, JW ;

MCNEILL, RM ;

LEWIN, AH ;

ABRAHAM, P ;

CARROLL, FI ;

KUHAR, MJ .

NEUROREPORT, 1992, 3 (11) :984-986

[2] A NEW SYNTHETIC APPROACH TO PENICILLINS [J].

COREY, EJ ;

FELIX, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (11) :2518-&

[3] Synthesis and pharmacology of potential cocaine antagonists .2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs [J].

Deutsch, HM ;

Shi, Q ;

GruszeckaKowalik, E ;

Schweri, MM .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (06) :1201-1209

[4] SYNTHESIS AND HYDROLYSIS OF SOME FUSED-RING BETA-LACTAMS [J].

EARLE, RH ;

HURST, DT ;

VINEY, M .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (16) :2093-&

[5] CONFORMATIONAL-ANALYSIS OF METHYLPHENIDATE AND ITS STRUCTURAL RELATIONSHIP TO OTHER DOPAMINE REUPTAKE BLOCKERS SUCH AS CFT [J].

FROIMOWITZ, M ;

PATRICK, KS ;

CODY, V .

PHARMACEUTICAL RESEARCH, 1995, 12 (10) :1430-1434

[6] BINDING OF D-THREO-[C-11]METHYLPHENIDATE TO THE DOPAMINE TRANSPORTER IN-VIVO - INSENSITIVITY TO SYNAPTIC DOPAMINE [J].

GATLEY, SJ ;

DING, YS ;

VOLKOW, ND ;

CHEN, RY ;

SUGANO, Y ;

FOWLER, JS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 281 (02) :141-149

[7]

IMAI N, 1987, CHEM PHARM BULL, V35, P2646

[8] DOPAMINE TRANSPORTER SITE-DIRECTED MUTATIONS DIFFERENTIALLY ALTER SUBSTRATE TRANSPORT AND COCAINE BINDING [J].

KITAYAMA, S ;

SHIMADA, S ;

XU, HX ;

MARKHAM, L ;

DONOVAN, DM ;

UHL, GR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (16) :7782-7785

[9] IPT - A NOVEL IODINATED LIGAND FOR THE CNS DOPAMINE TRANSPORTER [J].

KUNG, MP ;

ESSMAN, WD ;

FREDERICK, D ;

MEEGALLA, S ;

GOODMAN, M ;

MU, M ;

LUCKI, I ;

KUNG, HF .

SYNAPSE, 1995, 20 (04) :316-324

[10] ALPHA,ALPHA-DIFLUOROARYLACETIC ACIDS - PREPARATION FROM (DIETHYLAMINO)SULFUR TRIFLUORIDE AND ALPHA-OXOARYLACETATES [J].

MIDDLETON, WJ ;

BINGHAM, EM .

JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (14) :2883-2887

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