Histopathological evidence for an association of inflammation with ductal pin-like lesions but not with ductal adenocarcinoma in the prostate of the noble rat

被引:28
作者
Bernoulli, Jenni [1 ]
Yatkin, Emrah [1 ,2 ]
Laakso, Arto [1 ]
Anttinen, Mikael [1 ]
Bosland, Maarten [3 ,4 ]
Vega, Katherine [4 ]
Kallajoki, Markku [5 ]
Santti, Risto [1 ]
Pylkkaenen, Liisa [6 ]
机构
[1] Univ Turku, Inst Biomed, Dept Anat, FIN-20520 Turku, Finland
[2] Univ Istanbul, Fac Vet Med, Dept Histol & Embryol, Istanbul, Turkey
[3] Univ Illinois, Dept Pathol, Chicago, IL USA
[4] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA
[5] Univ Turku, Inst Biomed, Dept Pathol, FIN-20520 Turku, Finland
[6] Univ Turku, Dept Oncol, FIN-20520 Turku, Finland
关键词
prostate inflammation; prostatic intraepithelial neoplasia; prostate cancer; sex steroid; animal model;
D O I
10.1002/pros.20719
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
BACKGROUND. Chronic inflammation may contribute to the development of prostate cancer. The goal of this study was to determine the possible association of prostatic inflammation, prostatic intraepithelial neoplasia (PIN)-like lesion, and prostate cancer, and to assess the androgen and estrogen dependency of the early steps of carcinogenesis. METHODS. Noble rats were treated with testosterone and estradiol implants for 13, 18, or 26 weeks. Hormone dependency of the lesions was studied in a subset of animals by removing hormone implants for 3 weeks after 15 weeks treatment time. RESULTS. After treatment for 13 weeks, acute and chronic inflammation was found in the dorsolateral prostate lobes and both inflammation and PIN-like lesions were present in the periurethal area of the prostate in all animals (n = 8). Following hormone exposure for 18 and 26 weeks, inflammation in the prostate remained, and adenocarcinomas in the periurethal prostate area with no adjacent inflammation were observed in all 18 animals studied. When both hormone implants were removed after 15 weeks, PIN-like lesions progressed further to adenocarcinoma only in two of seven animals. When only the estradiol implants were removed, three of five animals developed adenocarcinomas. CONCLUSIONS. Even though adenocarcinomas were not morphologically associated with inflammation, PIN-like lesions preceding adenocarcinoma were found in close association with inflammation, pointing towards a possible initiator role of inflammation in the early steps of prostatic carcinogenesis. Further, these results indicate that both androgens and estrogens together play a significant role in the induction of inflammation and prostatic cancer in this model.
引用
收藏
页码:728 / 739
页数:12
相关论文
共 46 条
[1]
Mechanisms of T cell tolerance and suppression in cancer mediated by tumor-associated antigens and hormones [J].
Adler, Adam J. .
CURRENT CANCER DRUG TARGETS, 2007, 7 (01) :3-14
[2]
Barqawi Albaha, 2004, Journal of Urology, V171, pS5, DOI 10.1097/01.ju.0000108141.36320.59
[3]
Urodynamic changes in a noble rat model for nonbacterial prostatic inflammation [J].
Bernoulli, Jenni ;
Yatkin, Ernrah ;
Talvitie, Eva-Maria ;
Santti, Risto ;
Streng, Torni .
PROSTATE, 2007, 67 (08) :888-899
[4]
Bosland Maarten C, 2005, Rev Urol, V7 Suppl 3, pS4
[5]
INDUCTION AT HIGH-INCIDENCE OF DUCTAL PROSTATE ADENOCARCINOMAS IN NBL/CR AND SPRAGUE-DAWLEY HSD-SD RATS TREATED WITH A COMBINATION OF TESTOSTERONE AND ESTRADIOL-17-BETA OR DIETHYLSTILBESTROL [J].
BOSLAND, MC ;
FORD, H ;
HORTON, L .
CARCINOGENESIS, 1995, 16 (06) :1311-1317
[6]
Chemoprevention trials in men with prostate-specific antigen failure or at high risk for recurrence after radical prostatectomy: Application to efficacy assessment of soy protein [J].
Bosland, MC ;
Kato, I ;
Melamed, J ;
Taneja, S ;
Lepor, H ;
Torre, P ;
Walden, P ;
Zeleniuch-Jacquotte, A ;
Lumey, LH .
UROLOGY, 2001, 57 (4A) :202-204
[7]
Bostwick DG, 2000, PROSTATE, V43, P286
[8]
High-grade prostatic intraepithelial neoplasia [J].
Bostwick, DG ;
Qian, JQ .
MODERN PATHOLOGY, 2004, 17 (03) :360-379
[9]
Proliferative inflammatory atrophy of the prostate - Implications for prostatic carcinogenesis [J].
De Marzo, AM ;
Marchi, VL ;
Epstein, JI ;
Nelson, WG .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (06) :1985-1992
[10]
Inflammation in prostate carcinogenesis [J].
De Marzo, Angelo M. ;
Platz, Elizabeth A. ;
Sutcliffe, Siobhan ;
Xu, Jianfeng ;
Gronberg, Henrik ;
Drake, Charles G. ;
Nakai, Yasutomo ;
Isaacs, William B. ;
Nelson, William G. .
NATURE REVIEWS CANCER, 2007, 7 (04) :256-269