HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004

被引：24

作者：

Chakraborty, Rana ^{[1
]}

Smith, Colette J. ^{[2
]}

Dunn, David ^{[3
]}

Green, Hannah ^{[3
]}

Duong, Trinh ^{[3
]}

Doerholt, Kaya

Riordon, Andrew ^{[4
]}

Lyall, Hermione ^{[5
]}

Tookey, Pat ^{[6
]}

Butler, Karina ^{[7
]}

Sabin, Caroline A. ^{[2
]}

Gibb, Di ^{[3
]}

Pillay, Deenan ^{[8
,9
]}

机构：

[1] Univ London St Georges Hosp, Paediat Infect Dis Unit, London, England

[2] UCL Royal Free & Univ Coll Med Sch, Dept Primary Care & Populat Sci, London, England

[3] MRC, Clin Trials Unit, London W1N 4AL, England

[4] Royal Liverpool Childrens Hosp, London, England

[5] St Marys Hosp, London, England

[6] Inst Child Hlth, London, England

[7] Our Ladys Childrens Hosp Crumlin, Dublin, Ireland

[8] UCL Royal Free & Univ Coll Med Sch, Univ Coll, Ctr Virol, London, England

[9] Hlth Protect Agcy, Ctr Infect, London, England

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 05期

基金：

英国医学研究理事会;

关键词：

human immunodeficiency virus; children; genotyping; antiretroviral therapy; resistant mutations;

D O I：

10.1097/INF.0b013e3181646d6f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We reviewed HIV-1 genotypes from 200 of 979 (20%) HIV-infected children in the U.K. Collaborative HIV in Pediatric Study (CHIPS) cohort (343 resistance tests). Three of 44 samples had major primary resistance mutations before antiretroviral therapy. Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance.

引用

页码：457 / 459

页数：3

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