A functional role for hemostasis in early cancer development,.

被引：38

作者：

Boccaccio, C ^{[1
]}

Comoglio, PM ^{[1
]}

机构：

[1] Univ Turin, Sch Med, Div Mol Oncol, Inst Canc Res & Treatment, I-10060 Turin, Italy

来源：

CANCER RESEARCH | 2005年 / 65卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-05-2277

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Blood coagulation disorders have been known to be associated with cancer for many years. However, the mechanisms responsible for their relationship have not been understood. Recent work indicates that activation of the MET oncogene, which drives invasion and metastasis in cancer, can promote a cancer-associated thrombohemorrhagic syndrome that is mediated by transcriptional up-regulation of the procoagulation factors plasminogen activator inhibitor type-1 and cyclooxygenase-2. These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis.

引用

页码：8579 / 8582

页数：4

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