Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry

被引:364
作者
Vanderford, BJ [1 ]
Pearson, RA [1 ]
Rexing, DJ [1 ]
Snyder, SA [1 ]
机构
[1] So Nevada Water Author, Boulder City, NV 89005 USA
关键词
D O I
10.1021/ac034210g
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/MS), using electrospray ionization (ESI) in both positive and negative modes and atmospheric pressure chemical ionization in positive mode. Unlike many previous methods, a single SPE procedure using 1 L of water coupled to a simple LC method is used for all ionization modes. Instrument detection limits for most compounds were below 1.0 pg on column with reporting limits of 1.0 ng/L in water. Recoveries for most compounds in deionized water were greater than 80%. Sulfuric acid was found to be the preferred sample preservative, and structures of all MS/MS product ions are proposed. Matrix effects from waters with a high content of treated municipal effluent were observed in both ESI modes and are discussed in the paper.
引用
收藏
页码:6265 / 6274
页数:10
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