Impulsive choice induced in rats by lesions of the nucleus accumbens core

被引：676

作者：

Cardinal, RN ^{[1
]}

Pennicott, DR ^{[1
]}

Sugathapala, CL ^{[1
]}

Robbins, TW ^{[1
]}

Everitt, BJ ^{[1
]}

机构：

[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

来源：

SCIENCE | 2001年 / 292卷 / 5526期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1126/science.1060818

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Impulsive choice is exemplified by choosing a small or poor reward that is available immediately, in preference to a Larger but delayed reward. Impulsive choice contributes to drug addiction, attention-deficit/hyperactivity disorder, mania, and personality disorders, but its neuroanatomical basis is unclear. Here, we show that selective Lesions of the nucleus accumbens core induce persistent impulsive choice in rats. In contrast, damage to two of its afferents, the anterior cingulate cortex and medial prefrontal cortex, had no effect on this capacity. Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity.

引用

页码：2499 / 2501

页数：3

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