Limonoids from Khaya senegalensis

被引：46

作者：

Khalid, SA

Friedrichsen, GM

Kharazmi, A

Theander, TG

Olsen, CE

Christensen, SB

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen O, Denmark

[2] Univ Khartoum, Fac Pharm, Dept Pharmacognosy, Khartoum, Sudan

[3] Univ Copenhagen, Natl Hosp 7806, Dept Clin Microbiol, Ctr Med Parasitol, DK-2200 Copenhagen, Denmark

[4] Univ Copenhagen, Inst Med Microbiol & Immunol, DK-2200 Copenhagen N, Denmark

[5] Royal Vet & Agr Univ, Dept Chem, DK-1871 Frederiksberg, Denmark

来源：

PHYTOCHEMISTRY | 1998年 / 49卷 / 06期

关键词：

Khaya senegalensis; Meliaceae; antiprotozoal natural products; limonoids; 2,6-dihydroxyfissinolide; fissinolide; methyl; 3; beta-acetoxy-6-hydroxy-1-oxomeliac-14-enoate; leishmaniasis; malaria;

D O I：

10.1016/S0031-9422(98)00284-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new limonoid was isolated from the bark of Khaya senegalensis and identified as 2,6-dihydroxyfissinolide. The assignments of some signals in the C-13 NMR spectrum of fissinolide have been reversed and the signals of the H-1 NMR spectrum:of methyl 3 beta-acetoxy-6-hydroxy-1-oxomeliac-14-enoate have been assigned. The limonoids only showed moderate antiprotozoal activities. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1769 / 1772

页数：4

共 10 条

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