Hybrid vectors based on adeno-associated virus serotypes 2 and 5 for muscle-directed gene transfer

被引：171

作者：

Hildinger, M

Auricchio, A

Gao, G

Wang, L

Chirmule, N

Wilson, JM

机构：

[1] 204 Wistar Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Inst Human Gene Therapy, Dept Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Inst Human Gene Therapy, Dept Mol & Cellular Engn, Philadelphia, PA 19104 USA

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 13期

关键词：

D O I：

10.1128/JVI.75.13.6199-6203.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated fur muscle-directed gene transfer (called AAV215). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between AAV2/5 and AAV2. Interestingly, we saw no immunologic evidence of previous exposure to AAV5 capsids in a large population of healthy human subjects.

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页码：6199 / 6203

页数：5

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