The genetic basis of male infertility

被引：25

作者：

Bhasin, S ^{[1
]}

Ma, K ^{[1
]}

Sinha, I ^{[1
]}

Limbo, M ^{[1
]}

Taylor, WE ^{[1
]}

Salehian, B ^{[1
]}

机构：

[1] Charles R Drew Univ Med & Sci, Div Endocrinol Metab & Mol Med, Los Angeles, CA 90059 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1998年 / 27卷 / 04期

关键词：

D O I：

10.1016/S0889-8529(05)70041-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Defective spermatogenesis can be the end result of a multitude of causes, such as systemic disease, malnutrition, endocrinologic disorder, genetic defects, anatomic obstruction of the passage of spermatozoa, infections, and environmental toxins. A genetic basis of infertility is thought to exist in a majority of infertile men currently classified as having idiopathic infertility Despite advances in molecular technology, the pathophysiology of spermatogenic failure in a majority of infertile men remains unknown. Although a large number of genes and loci in experimental animals are associated with sterility, the human homologues of most of these genes have not been cloned yet. Infertility is a heterogeneous syndrome in men; therefore, it is likely that a multitude of genes and loci will be implicated in different infertility subsets.

引用

页码：783 / +

页数：24

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